ea0099ep410 | Adrenal and Cardiovascular Endocrinology | ECE2024
Kunz Sonja
, Dubinski Ilja
, Schiergens Katharina
, Hawley James
, Keevil Brian
, Reisch Nicole
, Reincke Martin
, Schmidt Heinrich
, Bidlingmaier Martin
Introduction: 11-ketotestosterone (11KT) and 11β-hydroxyandrostenedione (11OHA4) are new biomarkers for hyperandrogenic disorders. Steroids can be measured in saliva, allowing non-invasive sampling by patients. We modified a published LC-MS/MS method1 for quantification of 11-oxygenated androgens in saliva with respect to sample volume, extraction procedure and equipment, and assessed the potential impact of different sampling devices on results.<p class="a...